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Welcome to Parkinson Team! Our goal is the diffusion of quality information on Parkinson's disease. Parkinson Team also intends to share opinions, impressions and experiences of people linked to Parkinson's disease. I expect your participation. A big hug to everyone, Sonia

martes, 3 de mayo de 2011

El Terrier Tibetano pueden sufrir un trastorno neurológico relacionado con la enfermedad de Parkinson

La doctoranda Fabiana Farias, de la Universidad de Missouri (Estados Unidos), ha publicado un artículo a partir de las investigaciones de sus tesis doctoral en el cual explica que los perros de la raza Terrier Tibetano y las personas compartimos una mutación genética relacionada con desórdenes neurológicos, según se publica en la web Science Daily.
En los Terriers Tibetanos la mutación está ligada a la aparición de lipofuscinosis ceroide neuronal. En ésta enfermedad se produce una interferencia en la función nerviosa debido a que se acumula material de desecho en las neuronas. Esto produce en los perros demencia, descoordinación, agresividad, problemas visuales… Generalmente cuando llegan alrededor de los cinco años de edad. La lipofuscinosis ceroide neuronal aparece también en los seres humanos, con gran variedad de presentaciones clínicas, pero los síntomas son similares a los que se producen en los perros.
El grupo de investigación de Missouri ha utilizado el mapa del genoma canino y muestras de ADN de perros que sufrían la lipofuscinosis ceroide para detectar causas genéticas. Y la mutación que se detectó en el genoma de los perros es la misma que en los seres humanos produce un tipo de enfermedad de Parkinson hereditaria. Así que el problema de acumulación de material de desecho en las neuronas, que causa la lipofuscinosis, también parece estar relacionado con ese tipo de párkinson en personas.
A partir de aquí se abren dos caminos destacables: que se ponga a punto un test genético para los perros que permita eliminar a los portadores del gen mutado como reproductores, por un lado, y que los perros con esta mutación puedan servir para testar terapias génicas destinadas a los seres humanos, por otro.

Tibetan Terrier dogs can also be found in a fatal human neurological disorder related to Parkinson's disease.

Fabiana Farias, a doctoral candidate in Area Genetics at the University of Missouri, found the mutation as part of her thesis research. Gary Johnson, associate professor of Veterinary Pathobiology; Martin Katz, professor of Veterinary Pathobiology, and Dennis O'Brien, a professor in the Department of Veterinary Medicine and Surgery, along with a host of researchers from MU's College of Veterinary Medicine; College of Agriculture, Food and Natural Resources (CAFNR) and the Mason Eye Institute, recently published the findings in Neurobiology of Disease.
The disease in Tibetian Terriers is called adult-onset neuronal ceroid-lipofuscinosis (NCL). Within the dogs' cells in the brain and eye, material that should be "recycled" builds up and interferes with nerve cell function. Due to this buildup, around the age of five years old, the dog begins to exhibit dementia, impaired visual behavior, loss of coordination, and shows unwarranted aggression.
NCL ultimately took the life of Topper, a Tibetian Terrier owned by Lynn Steinhaus of Columbia. Steinhaus said Topper showed increased shyness around age five, and showed a loss of muscle control later. Topper also suffered seizures before he was euthanized in July of 2009. Topper's DNA was used to further the study.
"This is really hard disease for dog owners to go through," Steinhaus said. "Those seizures are just terrible."
While there are many forms of NCL in humans, the symptoms of NCL are similar in people and dogs, and the disease is ultimately fatal for both. Utilizing the canine genome map and DNA samples from dogs diagnosed with NCL, the researchers were able to pinpoint the specific gene that causes NCL. The mutation they discovered in dogs, however, causes a hereditary form of Parkinson's disease in humans. This suggests that the recycling that goes awry in NCL may also be involved in degenerative diseases like Parkinson's.
Now, DNA from dogs can be tested to identify the presence of the mutated gene, and that test can ensure that Tibetan Terrier breeders do not pass it on to the next generation. The researchers also believe that they may be able to test -potential human therapies on the animal population because they can use the DNA test to identify affected dogs before they start to show symptoms.
"Looking through samples collected from hundreds of dogs over many years, we got to the point where we're able to say this is a disease caused by the mutation of one gene," Katz said. "Finding that gene was like finding a single house in a very large city -- but we had the dog family history and the tools to look through the city in a systematic way to locate address of the mutation responsible for the disease."
The publication is the result of almost 10 years of work, and the researchers believe it couldn't have occurred without the unique combination of animal and human medical science at the University of Missouri.
"Dogs and people suffer from the same diseases, and it's much easier to discover gene issues in dogs because of the unique genetics of pure-bred dogs," O'Brien said. "Because we have a medical school and veterinary school near each other, we can find the genes in the dog and then find out if they cause a similar disease in people."

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