A new research report appearing in the December issue
of the FASEB Journal
shows how scientists from the United Kingdom have developed a simple blood test
to detect Parkinson's disease even at the earliest stages. The test is possible
because scientists found a substance in the blood, called "phosphorylated
alpha-synuclein," which is common in people with Parkinson's disease, and
then developed a way to identify its presence in our blood.
"A blood test for
Parkinson's disease would mean you could find out if a person was in danger of
getting the disease, before the symptoms started," said David Allsop,
Ph.D., a researcher involved in the work from the Division of Biomedical and
Life Sciences and the School of Health and Medicine at the University of Lancaster,
in Lancaster, UK. "This would help the development of medicines that could
protect the brain, which would be better for the quality of life and future
health of older people."
To develop the blood test for
Parkinson's disease, Allsop and colleagues studied a group of people diagnosed
with the disease and a second group of healthy people of a similar age. Blood
samples from each group were analyzed to determine the levels of phosphorylated
alpha-synuclein present. They found those with Parkinson's disease had
increased levels of the substance. Based upon these findings, researchers
developed a blood test that detects the presence of phosphorylated
alpha-synuclein, which could allow for diagnosis of the disease well before
symptoms appear but when brain damage has already begun to occur.
"When most people think of
Parkinson's disease, they think of the outward symptoms, such as involuntary
movements," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "but
many people with Parkinson's also develop neurological problems that may be
more difficult to detect right away. Having a blood test not only helps doctors
rule out other possible causes of the outward symptoms, but it also allows for
early detection which can help patients and their caregivers prepare for the
possibility of the mental, emotional, and behavioral problems that the disease
can cause."
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