¡Bienvenidos!

¡Bienvenidos Parkinson Team! Nuestro objetivo es la difusión de información de calidad sobre la enfermedad de Parkinson. Parkinson Team también pretende compartir las opiniones, impresiones y vivencias de las personas vinculadas a la enfermedad de Parkinson. Espero vuestra participación. Un abrazo a todos, Sonia

Welcome!

Welcome to Parkinson Team! Our goal is the diffusion of quality information on Parkinson's disease. Parkinson Team also intends to share opinions, impressions and experiences of people linked to Parkinson's disease. I expect your participation. A big hug to everyone, Sonia

jueves, 1 de septiembre de 2011

Crean células nerviosas cerebrales de un tipo de Parkinson que ayudará en el desarrollo de nuevos fármacos

Científicos de la Universidad de Edimburgo crean por primera vez células nerviosas cerebrales de un tipo de Parkinson de progresión muy rápida. Esta investigación ha sido publicada en Nature Communications y ayudará mucho en la investigación y desarrollo de nuevos fármacos.
Para crear estas células nerviosas del cerebro, los científicos usaron muestras de piel de un paciente el cual padece una forma de Parkinson que progresa muy rápidamente, el cual puede ser diagnosticado en la treintena. Aunque esta forma de Parkinson no es la más común, la proteína implicada está vinculada en la mayoría de casos de la enfermedad.
Al ser un tipo de Parkinson que progresa rápidamente, ayudará mejor a ver los efectos de los fármacos probados, y lograr el objetivo de encontrar fármacos que puedan prevenir la muerte de las neuronas que se descomponen a causa de esta enfermedad.

Stem cell study offers hope for Parkinson's patients

Scientists have for the first time generated stem cells from one of the most rapidly progressing forms of Parkinson's disease.
The development will help research into the condition as it will enable scientists to model the disease in the laboratory to shed light on why certain nerve cells die.
Scientists, funded with a £300,000 grant from the charity Parkinson's UK, took skin samples from a patient diagnosed with one of the most progressive types of Parkinson's.
The research, led by the University of Edinburgh in collaboration with UCL (University College London), then used these skin cells to generate brain nerve cells affected by the disease.
The ability to generate these nerve cells will make it easier to monitor the effectiveness of potential new drugs that could slow or halt progress of the condition.
The aim would be to find drugs that can prevent the death of these key cells - known as neurons - which break down as a result of Parkinson's.
Dr Tilo Kunath, of the University of Edinburgh's Medical Research Council Centre for Regenerative Medicine, said: "Current drugs for Parkinson's alleviate symptoms of the condition. Modelling the disease in a dish with real Parkinson's neurons enables us to test drugs that may halt or reverse the condition.
"This study provides an ideal platform to gain fresh insight into the condition, and opens a new area of research to discover disease-modifying drugs."
The neuron cells were generated from a patient with a form of Parkinson's that progresses rapidly and can be diagnosed in people in their early 30s.
People with this form of Parkinson's have twice as many of the genes that produce a protein - alpha synuclein - compared with the general population.
Although this form of Parkinson's is rare the protein involved is linked to virtually all types of the disease.
Dr Michael Devine, of the UCL Institute of Neurology said, "Understanding such a progressive form of the disease will give us insight into different types of Parkinson's. As this type of Parkinson's progresses rapidly it will also make it easier to pick up the effects of drugs tested to prevent nerve cells targeted by the disease from dying."
The research was published in the journal Nature Communications.
Dr Kieran Breen, Director of Research and Development at Parkinson's UK, said: "Although the genetic mutation that leads to this progressive form of Parkinson's is rare this exciting study has the potential to bring about a huge breakthrough in Parkinson's research.
"This is just the kind of innovative research that Parkinson's UK is committed to funding as we move closer to a cure."

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